Smart online app to better diagnose cancer

By GizBot Bureau

Scientists have developed an online tool that can help clinicians better differentiate the defects in individual tumour cells that appear to be similar.

Smart online app to better diagnose cancer

The open-source software, which is freely available online, is expected to help scientists better define the nature of a cancer and other diseases and improve their treatment.

SEE ALSO: Samsung Galaxy Note 5 launched in India starting at Rs 53,990: To go on sale from the 20th

Seemingly similar cells, especially cancer cells, often have significantly different genetic mutations and therefore detailed knowledge of these mutations, called copy number variations (CNVs), in individual cells can point to specific treatment regimens.

"You may think that every cell in a tumour would be the same, but that is actually not the case," said Michael Schatz, associate professor at Cold Spring Harbor Laboratory (CSHL) in New York, US.

"We are realising that there can be a lot of changes inside even a single tumour," Schatz noted.

"If you are going to treat cancer, you need to diagnose exactly what subclass of cancer you have," Schatz explained.

SEE ALSO: Sony Xperia Z5 vs Top 10 latest smartphones

The new interactive online programme called Gingko reduces the uncertainty of single-cell analysis and provides a simple way to visualise patterns in copy number mutations across populations of cells, the study said.

Copy number variation is a common mutation in which large chunks of DNA are either deleted from or added to the genome.

One powerful single-cell analytic technique for exploring CNV is whole genome sequencing. The challenge is that, before sequencing can be done, the cell's DNA has to be amplified many times over.

This process is rife with errors, with some arbitrary chunks of DNA being amplified more than others. In addition, because many labs use their own software to examine CNVs, there is little consistency in how researchers analyse their results.

SEE ALSO: 10 Best Smartphones Available to Buy in India [September 2015]

To address these two challenges, Schatz and his colleagues created Gingko.

The interactive, web-based programme automatically processes sequence data, maps the sequences to a reference genome, and creates CNV profiles for every cell that can then be viewed with a user-friendly graphical interface.

The software was described online in the journal Nature Methods.

Source IANS

Most Read Articles
Best Mobiles in India

Read More About: online windows

Best Phones

Get Instant News Updates
Notification Settings X
Time Settings
Clear Notification X
Do you want to clear all the notifications from your inbox?
Yes No
Settings X
We use cookies to ensure that we give you the best experience on our website. This includes cookies from third party social media websites and ad networks. Such third party cookies may track your use on Gizbot sites for better rendering. Our partners use cookies to ensure we show you advertising that is relevant to you. If you continue without changing your settings, we'll assume that you are happy to receive all cookies on Gizbot website. However, you can change your cookie settings at any time. Learn more